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to the Endothelin System David M. Pollock ascular endothelial cells form a monolayer lining in all of the blood vessels of V the circulation. Initially, they were thought to function as a crude filter allow ing nutrients from the blood stream to diffuse through to the underlying tissues without letting proteins or blood cells escape. We now know that endothelial cells are important regulators of circulatory function, due in large measure to their rec ognized ability to synthesize and release many factors that regulate vascular smooth muscle tone. Endothelial-derived factors, including relaxing and contracting sub stances such as prostacyclin, nitric oxide (NO), and endothelin (ET), have been identified as important contributors in the regulation of vascular tone. Endothe lial cells have a highly active metabolic function and are involved in clearing a number of agents from circulating blood. In addition, they have the enzyme that inactivates bradykinin and converts angiotensin I into the very potent pressor agent, angiotensin II (Ang II). Endothelial cells also generate various proteins like von Willebrand's factor, tissue plasminogen activator, growth promoting factors and lipids such as platelet activating factor. It is now clear that in addition to the regu lation of vascular tone and hemodynamics, endothelial cells playa critical role in regulating growth and proliferative processes, inflammation and hemostasis. Cell Signaling Journals Peer Reviewed High Impact Articles List of highly accessed peer reviewed open access articles in cell signaling cell signaling transduction. 2014 Journal rank impact factors and indexing. Protease Inhibitor Cocktails References Sigma-Aldrich Broad spectrum protease inhibitors and mixtures or Cocktails have been developed to help protect the integrity of proteins during the protein extraction and ... Endothelin receptor - Wikipedia endothelin receptor type B; Identifiers; Symbol: EDNRB: Alt. symbols: HSCR2 HSCR: Entrez: 1910: HUGO: 3180: OMIM: 131244: RefSeq: NM_000115: UniProt: P24530: Other ... Annual Review of Pharmacology and Toxicology - Home The Annual Review of Pharmacology and Toxicology in publication since 1961 covers the significant developments in the fields of pharmacology and toxicology ... SturgeWeber Syndrome and Port-Wine Stains Caused by ... Original Article. SturgeWeber Syndrome and Port-Wine Stains Caused by Somatic Mutation in GNAQ. Matthew D. Shirley Ph.D. Hao Tang Ph.D. Carol J. Gallione B.A ... Endothelin - Wikipedia Endothelin family; Identifiers; Symbol: Endothelin: Pfam: PF00322: InterPro: IPR001928: PROSITE: PDOC00243: SCOP: 1edp: SUPERFAMILY: 1edp: OPM superfamily: 156: OPM ... Physical exercise -adrenergic receptors and vascular ... Jornal Vascular Brasileiro Print version ISSN 1677-5449 J. vasc. bras. vol.9 no.2 Porto Alegre June 2010 dx.doi.org/10.1590/S1677-54492010000200007 Melanoma NEJM Photosensitivity Tanning and Melanoma. The effect of exposure to ultraviolet light is governed by variations in particular genes (polymorphisms) that affect both ...
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